← DISCOVERY / IBOGAINE

Ibogaine

Complex pharmacology including NMDA antagonism, serotonin reuptake inhibition, and sigma receptor activity. Famous for interrupting opioid addiction and producing long, dream-like visionary states.

oneirogenpsychedelic
Chemical structure of Ibogaine
Structure · Wikimedia contributor See Wikimedia
THREE-DIMENSIONAL STRUCTURE

The molecule, in space.

Atoms positioned in their lowest-energy 3D geometry, sourced from PubChem. Drag to rotate · pinch or scroll to zoom · switch between stick, sphere, and line representations to feel the shape from different angles.

3D structure · PubChem CID 197060 · drag to rotate · scroll to zoom
SMILES NOTATION
CC[C@H]1C[C@@H]2C[C@@H]3[C@H]1N(C2)CCC4=C3NC5=C4C=C(C=C5)OC
PubChem CID 197060 →
RECEPTOR PROFILE

The pharmacological targets through which this compound exerts its effects.

NMDA antagonist5-HT reuptakeKappa-opioid
NATURAL SOURCES

Living organisms in which this compound is naturally found.

Tabernanthe iboga (Iboga)
plant
Congolian rainforest
Tabernanthe iboga
Iboga

Shrub native to Central Africa containing ibogaine, a unique indole alkaloid with powerful anti-addictive and oneirogenic properties.

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Voacanga africana (Voacanga)
plant
Afrotropical
Voacanga africana
Voacanga

West African tree closely related to iboga whose bark and seeds are exceptionally rich in voacangine — a chemical precursor and close analog of ibogaine — and which is used by some Bwiti initiates as a substitute for, or complement to, Tabernanthe iboga.

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REFERENCES
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RELATED MOLECULES

Other ibogaines

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Chemical structure of Noribogaine
Ibogaine
Half-life 28–49 hours
Noribogaine
12-Hydroxyibogamine
oneirogen

Active metabolite of ibogaine, formed by demethylation in the liver. Substantially longer half-life than the parent compound and a notable serotonin reuptake inhibitor — widely considered responsible for much of ibogaine's anti-addictive afterglow.

Tabernanthe iboga
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Chemical structure of Voacangine
Ibogaine
12–24 hours
Voacangine
psychedeliconeirogen

Iboga-type alkaloid found in Voacanga africana and Tabernanthe iboga and used industrially as the precursor for ibogaine synthesis. Pharmacologically similar to ibogaine but somewhat weaker.

Tabernaemontana undulataTabernanthe ibogaVoacanga africana
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