← DISCOVERY / MUSCIMOL

Ibotenic Acid

Excitotoxic glutamate-receptor agonist (NMDA and AMPA) found in Amanita muscaria and A. pantherina. Decarboxylates to the much less excitotoxic muscimol when the mushroom is dried, aged, or passed through a mammalian kidney — which is why dried muscaria (and reindeer-filtered urine) are traditionally preferred over fresh.

deliriant
Chemical structure of Ibotenic Acid
Structure · Wikimedia contributor See Wikimedia
THREE-DIMENSIONAL STRUCTURE

The molecule, in space.

Atoms positioned in their lowest-energy 3D geometry, sourced from PubChem. Drag to rotate · pinch or scroll to zoom · switch between stick, sphere, and line representations to feel the shape from different angles.

3D structure · PubChem CID 1233 · drag to rotate · scroll to zoom
SMILES NOTATION
C1=C(ONC1=O)C(C(=O)O)N
PubChem CID 1233 →
RECEPTOR PROFILE

The pharmacological targets through which this compound exerts its effects.

NMDA agonistAMPA agonistGlutamate analog
NATURAL SOURCES

Living organisms in which this compound is naturally found.

Amanita pantherina (Panther Cap)
fungus
Palearctic
Amanita pantherina
Panther Cap

Close relative of the fly agaric whose tan-brown cap conceals a substantially higher concentration of ibotenic acid and muscimol — making it both more potent and more dangerous than A. muscaria.

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REFERENCES
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RELATED MOLECULES

Other muscimols

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Chemical structure of Muscimol
Muscimol
6–12 hours
Muscimol
sedativeoneirogen

Potent GABA-A receptor agonist. Primary psychoactive compound in Amanita muscaria responsible for sedative, oneirogenic, and deliriant-like effects.

Amanita muscariaAmanita pantherina
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