Best-characterized of the kavalactones of Piper methysticum. Modulates GABA-A receptors and inhibits voltage-gated sodium and calcium channels — producing a clear-headed, sociable anxiolytic effect quite distinct from alcohol or benzodiazepines.
Atoms positioned in their lowest-energy 3D geometry, sourced from PubChem. Drag to rotate · scroll to zoom · switch between stick, sphere, and line representations to feel the shape from different angles.
COC1=CC(OC(=C1)/C=C/C2=CC=CC=C2)=O The pharmacological targets through which this compound exerts its effects.
Living organisms in which this compound is naturally found.
The most widely consumed psychoactive substance on Earth. Acts primarily as a competitive antagonist of adenosine receptors, indirectly raising dopamine, norepinephrine, and acetylcholine signaling — producing wakefulness, alertness, and mild euphoria.
Excitotoxic glutamate-receptor agonist (NMDA and AMPA) found in Amanita muscaria and A. pantherina. Decarboxylates to the much less excitotoxic muscimol when the mushroom is dried, aged, or passed through a mammalian kidney — which is why dried muscaria (and reindeer-filtered urine) are traditionally preferred over fresh.
Principal alkaloid of fermented Sceletium tortuosum. A selective serotonin reuptake inhibitor and PDE4 inhibitor with mild mood-elevating, anxiolytic, and pro-social effects.
Potent GABA-A receptor agonist. Primary psychoactive compound in Amanita muscaria responsible for sedative, oneirogenic, and deliriant-like effects.
