← DISCOVERY / INDOLE ALKALOID

7-Hydroxymitragynine

7-OH-mitragynine

Oxidized minor alkaloid and active metabolite of mitragynine. Substantially more potent at the mu-opioid receptor than mitragynine itself — believed responsible for much of kratom's analgesic and sedative effect at higher leaf doses.

sedative
Chemical structure of 7-Hydroxymitragynine
Structure · Wikimedia contributor See Wikimedia
THREE-DIMENSIONAL STRUCTURE

The molecule, in space.

Atoms positioned in their lowest-energy 3D geometry, sourced from PubChem. Drag to rotate · scroll to zoom · switch between stick, sphere, and line representations to feel the shape from different angles.

3D structure · PubChem CID 44301117 · drag to rotate · scroll to zoom
SMILES NOTATION
CCC1CN(C2)CCC3=C2N(C4=CC=CC=C34)C/C1=C(\OC)C(=O)OC
PubChem CID 44301117 →
RECEPTOR PROFILE

The pharmacological targets through which this compound exerts its effects.

μ-opioid partial agonistκ-opioid antagonistδ-opioid antagonist
REFERENCES
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RELATED MOLECULES

Other indole alkaloids

All compounds →
Chemical structure of Mitragynine
Indole
3–6 hours
Mitragynine
stimulantsedative

Principal alkaloid of kratom leaves. Acts as a partial agonist at mu-opioid receptors and an antagonist at kappa and delta — an unusual profile that produces stimulation at low doses and opioid-like effects at higher doses. Also modulates adrenergic and serotonergic systems.

Mitragyna speciosa
Examine →