Aporphine alkaloid of sacred and blue lotus. Acts as a dopamine D2 antagonist and weak partial agonist at several serotonin receptors — producing mild sedation, calm, and a subtly dreamy mood-lift.
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CN1CCC2=CC(=C(C3=C2[C@H]1CC4=CC=CC=C43)OC)OC The pharmacological targets through which this compound exerts its effects.
Living organisms in which this compound is naturally found.
Pyridine alkaloid acting as a partial muscarinic acetylcholine receptor agonist. The primary psychoactive constituent of betel/areca nut, producing mild stimulation, warmth, and a sense of well-being alongside well-documented carcinogenic risk to oral tissues with chronic use.
Phenylpropanoid found in Acorus calamus and Asarum species. Mechanism remains incompletely understood; mild psychoactive, sedative, and tonic effects have been described historically. β-asarone, a related isomer, is classified as a probable carcinogen and is the reason calamus from Indian-strain plants is regulated as a food additive.
Isoquinoline alkaloid widespread in Berberis, Hydrastis, Argemone, Coptis and many other genera. Not classically psychoactive — included for completeness as a major alkaloid of several plants in the atlas. Active research target for metabolic and cardiovascular conditions.
The most widely consumed psychoactive substance on Earth. Acts primarily as a competitive antagonist of adenosine receptors, indirectly raising dopamine, norepinephrine, and acetylcholine signaling — producing wakefulness, alertness, and mild euphoria.
