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Scopolamine

Hyoscine

Tropane alkaloid found in Brugmansia, Datura, and other Solanaceae. Acts as a competitive muscarinic acetylcholine receptor antagonist, producing intense deliriant effects qualitatively distinct from classical psychedelics — including realistic hallucinations indistinguishable from reality.

deliriant
THREE-DIMENSIONAL STRUCTURE

The molecule, in space.

Atoms positioned in their lowest-energy 3D geometry, sourced from PubChem. Drag to rotate · scroll to zoom · switch between stick, sphere, and line representations to feel the shape from different angles.

3D structure · PubChem CID 5184 · drag to rotate · scroll to zoom
SMILES NOTATION
CN1[C@@H]2CC([C@H]1[C@H]3[C@@H]2O3)OC(=O)C(CO)C4=CC=CC=C4
PubChem CID 5184 →
RECEPTOR PROFILE

The pharmacological targets through which this compound exerts its effects.

Muscarinic acetylcholine antagonist (non-selective)
NATURAL SOURCES

Living organisms in which this compound is naturally found.

Atropa belladonna (Deadly Nightshade)
plant
Palearctic
Atropa belladonna
Deadly Nightshade

European perennial whose glossy black berries and dull-green leaves contain a lethal cocktail of tropane alkaloids — long associated with witchcraft, flying ointments, and Atropos, the Greek Fate who cuts the thread of life.

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Brugmansia suaveolens (Angel's Trumpet)
plant
Neotropical
Brugmansia suaveolens
Angel's Trumpet

Tree with enormous fragrant pendulous flowers, containing the tropane alkaloids scopolamine, atropine, and hyoscyamine. Produces a deeply deliriant, dissociative state that many traditional practitioners describe as fundamentally different from — and more dangerous than — the tryptamine entheogens.

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Datura stramonium (Jimsonweed)
plant
Nearctic
Datura stramonium
Jimsonweed

Cosmopolitan weedy annual whose spiny seed pods conceal an extremely dangerous mixture of tropane alkaloids — producing intense, fully formed hallucinations indistinguishable from reality, often followed by amnesia and lasting physical harm.

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Hyoscyamus niger (Henbane)
plant
Palearctic
Hyoscyamus niger
Henbane

Sticky, foul-smelling Eurasian biennial whose dusky cream-and-purple flowers conceal high levels of hyoscyamine and scopolamine — an ingredient of pre-Christian European ritual, classical antiquity's Oracle at Delphi (per some scholars), and the witches' Sabbath of medieval folklore.

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Mandragora officinarum (Mandrake)
plant
Palearctic
Mandragora officinarum
Mandrake

Mediterranean perennial whose forked, vaguely human-shaped root has accumulated more folklore per gram than perhaps any plant in the European tradition — from the Hebrew Bible to Pythagoras, Pliny, and Harry Potter.

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REFERENCES
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  • Schultes 1979
  • Renner 1973
RELATED MOLECULES

Other tropanes

All compounds →