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Scopolamine

Hyoscine

Tropane alkaloid found in Brugmansia, Datura, and other Solanaceae. Acts as a competitive muscarinic acetylcholine receptor antagonist, producing intense deliriant effects qualitatively distinct from classical psychedelics — including realistic hallucinations indistinguishable from reality.

deliriant
THREE-DIMENSIONAL STRUCTURE

The molecule, in space.

Atoms positioned in their lowest-energy 3D geometry, sourced from PubChem. Drag to rotate · pinch or scroll to zoom · switch between stick, sphere, and line representations to feel the shape from different angles.

3D structure · PubChem CID 5184 · drag to rotate · scroll to zoom
SMILES NOTATION
CN1[C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4
PubChem CID 5184 →
RECEPTOR PROFILE

The pharmacological targets through which this compound exerts its effects.

Muscarinic acetylcholine antagonist (non-selective)
NATURAL SOURCES

Living organisms in which this compound is naturally found.

Atropa belladonna (Deadly Nightshade)
plant
Palearctic
Atropa belladonna
Deadly Nightshade

European perennial whose glossy black berries and dull-green leaves contain a lethal cocktail of tropane alkaloids — long associated with witchcraft, flying ointments, and Atropos, the Greek Fate who cuts the thread of life.

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Brugmansia suaveolens (Angel's Trumpet)
plant
Neotropical
Brugmansia suaveolens
Angel's Trumpet

Tree with enormous fragrant pendulous flowers, containing the tropane alkaloids scopolamine, atropine, and hyoscyamine. Produces a deeply deliriant, dissociative state that many traditional practitioners describe as fundamentally different from — and more dangerous than — the tryptamine entheogens.

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Datura stramonium (Jimsonweed)
plant
Nearctic
Datura stramonium
Jimsonweed

Cosmopolitan weedy annual whose spiny seed pods conceal an extremely dangerous mixture of tropane alkaloids — producing intense, fully formed hallucinations indistinguishable from reality, often followed by amnesia and lasting physical harm.

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Hyoscyamus niger (Henbane)
plant
Palearctic
Hyoscyamus niger
Henbane

Sticky, foul-smelling Eurasian biennial whose dusky cream-and-purple flowers conceal high levels of hyoscyamine and scopolamine — an ingredient of pre-Christian European ritual, classical antiquity's Oracle at Delphi (per some scholars), and the witches' Sabbath of medieval folklore.

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Latua pubiflora (Latué)
plant
Andean
Latua pubiflora
Latué

Rare, endemic tree of southern Chile's temperate rainforest, the only member of its genus. Contains scopolamine and hyoscyamine. Used historically by Mapuche machis (shamans) in southern Chile — feared and revered as a tree of madness, vision, and witchcraft.

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Mandragora officinarum (Mandrake)
plant
Palearctic
Mandragora officinarum
Mandrake

Mediterranean perennial whose forked, vaguely human-shaped root has accumulated more folklore per gram than perhaps any plant in the European tradition — from the Hebrew Bible to Pythagoras, Pliny, and Harry Potter.

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Solandra brevicalyx (Chalice Vine)
plant
Neotropical
Solandra brevicalyx
Chalice Vine

Mexican woody climber of the nightshade family with very large pale-yellow trumpet flowers. Contains the classic tropane alkaloids scopolamine and hyoscyamine at substantial concentration. Held sacred by the Huichol people, who call it kieli or kieri and treat it as a powerful, dangerous spirit.

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REFERENCES
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  • Schultes 1979
  • Renner 1973
RELATED MOLECULES

Other tropanes

All compounds →