← DISCOVERY / TRYPTAMINE

Psilocin

4-HO-DMT

The active dephosphorylated metabolite of psilocybin. Direct 5-HT2A agonist responsible for the classic psychedelic effects of magic mushrooms.

psychedelic
THREE-DIMENSIONAL STRUCTURE

The molecule, in space.

Atoms positioned in their lowest-energy 3D geometry, sourced from PubChem. Drag to rotate · scroll to zoom · switch between stick, sphere, and line representations to feel the shape from different angles.

3D structure · PubChem CID 5280441 · drag to rotate · scroll to zoom
SMILES NOTATION
CN(C)CC1=CNC2=CC=CC(=C21)O
PubChem CID 5280441 →
RECEPTOR PROFILE

The pharmacological targets through which this compound exerts its effects.

5-HT2A agonist5-HT2C5-HT1A
NATURAL SOURCES

Living organisms in which this compound is naturally found.

Gymnopilus luteoviridis (Yellow-Green Gymnopilus)
fungus
Nearctic
Gymnopilus luteoviridis
Yellow-Green Gymnopilus

Wood-decaying rust-spored mushroom whose bright golden flesh contains psilocybin alongside an intensely bitter taste — a chemical combination that has prevented it from ever becoming popular for recreational use.

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Inocybe aeruginascens (Aeruginous Fibrecap)
fungus
Palearctic
Inocybe aeruginascens
Aeruginous Fibrecap

Small European fibrecap that, uniquely within an otherwise toxic genus, produces psilocybin, baeocystin, and the quaternary tryptamine aeruginascin — the latter discovered through accidental poisonings.

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Panaeolus cinctulus (Banded Mottlegill)
fungus
Palearctic
Panaeolus cinctulus
Banded Mottlegill

Widely distributed, moderately potent psilocybin-containing mushroom — one of the most common temperate dung and compost species, and often the first encountered by accidental foragers.

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Panaeolus cyanescens (Copelandia cyanescens)
fungus
Neotropical
Panaeolus cyanescens
Copelandia cyanescens

Pantropical dung-loving mushroom widely regarded as one of the most potent natural sources of psilocybin and psilocin — often several times stronger by weight than Psilocybe cubensis.

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Psilocybe azurescens (Flying Saucer Mushroom)
fungus
Nearctic
Psilocybe azurescens
Flying Saucer Mushroom

One of the most potent psilocybin-containing mushrooms in the world. Produces exceptionally high levels of psilocybin and psilocin.

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Psilocybe baeocystis (Bottle Cap)
fungus
Nearctic
Psilocybe baeocystis
Bottle Cap

Wood-loving Pacific Northwest mushroom and the type species for the alkaloid baeocystin. Often dark, sticky, and prone to staining a deep indigo blue.

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Psilocybe cubensis (Golden Teacher)
fungus
Neotropical
Psilocybe cubensis
Golden Teacher

One of the most widely cultivated and studied psilocybin-producing mushrooms. Cosmopolitan species with a distinctive golden cap and strong blue bruising reaction.

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Psilocybe cyanescens (Wavy Cap)
fungus
Nearctic
Psilocybe cyanescens
Wavy Cap

Highly potent wood-loving psilocybin mushroom famous for its wavy cap margin and intense blue bruising. One of the strongest naturally occurring species in temperate climates.

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Psilocybe mexicana (Teonanácatl)
fungus
Neotropical
Psilocybe mexicana
Teonanácatl

Small psilocybin mushroom historically used in sacred mushroom ceremonies by the Mazatec and other indigenous groups in Mexico.

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Psilocybe natalensis (Natal Super Strength)
fungus
Afrotropical
Psilocybe natalensis
Natal Super Strength

Southern African dung-loving psilocybin mushroom morphologically similar to P. cubensis but adapted to subtropical grassland conditions.

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Psilocybe semilanceata (Liberty Cap)
fungus
Palearctic
Psilocybe semilanceata
Liberty Cap

Small, potent, conical-capped mushroom that is among the most widespread psilocybin species in temperate regions.

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Psilocybe tampanensis (Philosopher's Stone)
fungus
Nearctic
Psilocybe tampanensis
Philosopher's Stone

Rare wild mushroom famous for producing dense underground sclerotia — the so-called 'magic truffles' that have become the legal substrate for psilocybin retreats and microdosing in the Netherlands.

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Psilocybe zapotecorum (Hongo de los Zapotecas)
fungus
Neotropical
Psilocybe zapotecorum
Hongo de los Zapotecas

Robust, dark-spored mushroom of Mesoamerican cloud forests, used ceremonially by Zapotec, Chatino, and Mixe peoples and considered one of the sacred 'teonanácatl' species.

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REFERENCES
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